Cairo University is set to launch a groundbreaking clinical trial to compare the performance and durability of CAD/CAM metallic partial denture frameworks against conventional metallic frameworks for patients with mandibular Kennedy Class III dental conditions. This study will evaluate key aspects of prosthetic dentistry, focusing on occlusion and longevity to enhance patient outcomes.
What is the study about?
The trial will explore two types of metallic denture frameworks. The CAD/CAM approach uses computer-aided design and manufacturing to craft precision dentures, while the conventional method relies on traditional techniques. Both will be evaluated based on their ability to provide effective occlusion and long-lasting performance in patients classified under mandibular Kennedy Class III.
Mandibular Kennedy Class III refers to a partial edentulism condition characterized by several missing teeth within one arch while healthy teeth remain on either side of the edentulous space. Choosing the optimum denture framework is crucial for maintaining oral health, restoring function, and ensuring patient comfort.
What changed?
The trial is sponsored by Cairo University and is currently marked as “Not yet recruiting” as of October 11, 2025. Once launched, the study will focus on comparing the efficacy of CAD/CAM and conventional frameworks to provide evidence-backed recommendations for clinical practice. Healthcare providers and regulatory professionals are encouraged to monitor updates regarding trial initiation and findings.
The use of CAD/CAM technology in prosthetic dentistry has gained significant momentum in recent years. This study highlights the need for clinical validation to determine its advantages over well-established traditional fabrication methods for frameworks.
Implications for prosthetic dentistry
This clinical trial holds promise for advancing prosthetic dentistry, especially for mandibular Kennedy Class III cases. If proven more effective, CAD/CAM frameworks could lead to streamlined manufacturing processes, better fit, and potentially improved long-term performance.
Healthcare and regulatory teams will gain insight into whether CAD/CAM frameworks meet durability and occlusion standards necessary for routine clinical use. Guidelines and regulations could evolve based on the results, further integrating digital design and manufacturing technologies into prosthetic dental practices.
FAQ
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What is the difference between CAD/CAM and conventional frameworks?
CAD/CAM frameworks use computer-aided design and manufacturing for precision, while conventional frameworks are handmade using traditional methods. -
Why is the study focusing on Kennedy Class III cases?
Kennedy Class III represents a partial edentulism condition that is common in dental practices, making it a valuable focus for clinical trials involving denture frameworks. -
What are the criteria for framework evaluation?
Key criteria include occlusion and prosthesis durability during routine use.
Conclusion
The upcoming trial by Cairo University addresses a significant research gap in the comparative effectiveness of CAD/CAM versus conventional metallic denture frameworks. Dental healthcare providers, regulatory personnel, and technology developers must keep a close eye on this study to adapt practices and policies accordingly as its findings may reshape standards in the field.
Disclaimer
This article is for informational purposes only and does not constitute legal or medical device regulatory advice. Professionals should consult appropriate legal and regulatory guidelines for decision-making.
Announcement details
For full information about the announcement, see the link below.
https://clinicaltrials.gov/study/NCT07215208?term=medical+device