November 18, 2025 — Istinye University has announced a new clinical trial focused on reducing postoperative pain in living liver donors. This study investigates the effectiveness of the Rectus Intercostal Plane Block compared to no intervention. While recruitment is not yet open, this clinical trial promises advancements in perioperative pain management for liver transplantation patients.
In this article:
- What changed?
- How will the trial be conducted?
- Why is postoperative pain management critical?
- Frequently asked questions
- Conclusion and implications
- Disclaimer
- Announcement link
What changed?
Istinye University is leading a study to assess the potential benefits of the Rectus Intercostal Plane Block in decreasing postoperative pain for living liver donors. Though recruitment has not yet started, the trial demonstrates a growing focus on minimizing patient discomfort during recovery from complex surgical procedures.
The study compares two groups: one receiving the Rectus Intercostal Plane Block and a control group with no intervention. Postoperative pain management is central to improving patient outcomes, and this study aligns with the global demand for better recovery protocols in liver transplantation surgeries.
How will the trial be conducted?
The trial is categorized under interventional conditions targeting liver transplantation donors who will undergo surgery. Researchers plan to administer the Rectus Intercostal Plane Block to one group, while another group will serve as a control. The comparison focuses on pain perceptions and recovery outcomes between these groups.
The intervention — a Rectus Intercostal Plane Block — involves targeting specific nerve areas to manage pain during abdominal surgeries. Data collected during this trial may affect protocols in similar procedures moving forward.
Why is postoperative pain management critical?
Liver transplantation surgeries are complex and can lead to significant postoperative discomfort. Managing pain effectively is essential to ensure active recovery, reduce stress on the donor’s body, and improve both physical and emotional well-being.
The Rectus Intercostal Plane Block intervention could offer safer and more targeted pain relief, decreasing the reliance on opioid medications. Results from the trial could ultimately influence standard procedures across healthcare institutions.
Frequently asked questions
1. Who is conducting this trial?
The trial is sponsored by Istinye University located in Turkey.
2. When will recruitment begin?
The trial is currently listed as not yet recruiting. Further updates will define participant timelines.
3. What types of interventions will be studied?
Two interventions will be evaluated: the Rectus Intercostal Plane Block, and a control method with no block.
4. Which population does this trial target?
The focus is on living donors who undergo liver transplantation surgery.
Conclusion and implications
Living liver donors often endure significant pain during recovery from transplantation surgeries. Studies like the one conducted by Istinye University aim to provide new options for effective pain management. While recruitment has not yet started, updates from this trial will be highly anticipated by clinical teams, regulators, and medical device manufacturers worldwide.
Stakeholders should monitor this trial for findings that could impact transplant-related recovery protocols globally.
Disclaimer
This article is intended for informational purposes for clinical, quality, and regulatory teams. It should not be treated as legal advice. Always consult relevant regulatory guidance and medical standards.
Announcement link
For full information about the announcement, see the link below.
https://clinicaltrials.gov/study/NCT07233096?term=medical+device